Ruthenium polypyridyl complexes have been shown to photocleave and photobind with DNA, a unique property of photodynamic therapy agents (PDT). Incorporation of a sterically strained Ru-based chromophore to a cis-PtCl2 moiety yields complexes capable of covalently binding to DNA upon photoirradiation through Ru(II) chromophore unit along with covalent binding through cisplatin moiety. Herein we will present design, synthesis, spectroscopic electrochemical, and photochemical properties of a series of bimetallic complexes, including [Ru(6-Mebpy)2dppPtCl2]2+, [Ru(4,4-Me2bpy)2dppPtCl2]2+, [Ru(6-Mebpy)2dpqPtCl2]2+, and [Ru(6-Mebpy)2dpbPtCl2]2+ (where dpp= 2,3-bis(2-pyridyl)pyrazine, dpq = 2,3-bis(2-pyridyl)quinoxaline, dpb = 2,3-bis(2-pyridyl)benzoquinoxaline, 6-Mebpy = 6-methyl-2,2’-dipyridyl, and 4,4-Me2bpy = 4,4’-dimethyl-2,2’-bipyridine). The impact of substituent position on terminal ligand and size and structure of bridging ligands on electrochemical and photochemical properties will be discussed.

Tuning the spectroscopic, electrochemical, and photochemical properties of Ru-Pt bimetallic complexes by varying ligand structure and substituents

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.