Upon introduction into environmental or biological fluids, nanoparticles rapidly aquire coatings of natural organic matter or biomolecules, commonly referred to as coronas. Acquisition of coronas alters the electrokinetic and hydrodynamic properties of nanoparticles and can affect their aggregation state. The surface properties of nanoparticles in environmental and biological milieus thus diverge from those that the nanoparticle was engineered to possess, impacting their interactions with environmental and biological surfaces. We have demonstrated that the initial surface chemistry of nanoparticles governs the ensemble of proteins that associate with them, which in turn influences subsequent interactions with model biological membranes. We will discuss recent work on the influence of nanoparticle surface chemistry on the composition of acquired coronas.

Influence of nanoparticle coatings on corona composition

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.