Supramolecular chemistry has found useful application in chemistry, with cucurbit[n]urils (CB[n]) exhibiting unique chemical properties. By the use of primarily hydrophobic interactions, these macrocycles can bind various small molecules with high binding constants in the range of 106 to 1012 M-1. The potential applications of these host guest systems can include molecular machines, drug delivery, and the purification of water. The binding modes and equilibrium binding constants have been studied for a series of alkyne-containing guest structures with CB[7] and CB[8]. These structures have been chosen for their potential for building more complex host-guest systems through organic synthesis.

Synthesis of alkyne-containing guests and their host-guest binding with cucurbit[7]uril and curburbit[8]uril

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.