Samples of generic formulation tablets containing 220 mg of naproxen sodium, 168 mg of acetaminophen or 200 mg of ibuprofen were exposed under low or high humidity conditions.  The release of each drug after equilibration under their respective humidity system were exposed to pH = 8.00, phosphate buffer in a dissolution apparatus at 37<sup>o</sup>C.  The rate of drug release from each tablet delivery systems were measured by collecting 5.0 mL samples at 1.0 minute intervals over a period of 90.0 minutes.  After collection of the samples was complete the samples were quantitated using a UV spectrophotometer.  Naproxen Sodium measured at 330 nm, acetaminophen at 250 nm and ibuprofen at 221 nm.  The data was then plotted using a three dimensional kinetic model to identify the release kinetics and obtain the rate constant for each drug.  The results observed, based on these dissolution studies, suggest that the rate of drug release from each formulation either increases or decreases when compared to the control, depending on the humidity condition the system was exposed to.      <br/> <br/>

Investigation of the release mechanism of naproxen sodium, acetaminophen and ibuprofen from tablet delivery systems under different humidity conditions

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.