The goal is to functionally classify proteins using their active sites. This method will lead to a detailed understanding of the molecular functional mechanisms. This research can be further used in phosducin research and drug development. The phosducin proteins are mainly found in the retina and bind to G-proteins. Phosducins are also found in other parts of the body, but its other functions are not determined. We classified the phosducin family using auto multi-iterative search sequencing technique (MISST), a set of computer scripts that incorporates Active Site Profiling (ASP), and Deacon Active Site Profiler 3 (DASP3). The program searches protein databases to cluster proteins with similar active site profiles. We have classified phosducins into two functional families. We are also classifying the phosducins on whether they have the binding site. This analysis reveals interesting functional details of this protein family.<br/>

Clustering of the phosducin protein family and its functionally relevant groups

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.