Pancreatic cancer is one of the deadliest human malignancies, with a 5-year survival rate of less than 5%. Its high mortality rate is primarily due to limited early detection techniques and treatments against the disease. Targeting the unique survival mechanism of pancreatic tumors under nutrient-starved environments, our group has developed a series of novel isoprenylated coumarin compounds that demonstrate anti-cancer activity against pancreatic adenocarcinoma cell line PANC-1 selectively under nutrient-deprived conditions. This study further investigates the effects of chiral substituents on compound cytotoxicity under nutrient-deprived conditions.<br/> <br/>

Investigating the effects of chirality on the cytotoxic activity of isoprenylated coumarin compounds against pancreatic cancer cells

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.