Gold nanoparticles (AuNPs) are widely explored for many biomedical research applications such as drug delivery, imaging, and fluorescence-based assays or sensors. Their surface modification allows for the attachment of targeting moieties for site-directed delivery to specific tissues and cells as well as fluorescent markers for visualizing uptake and retention in cellular environments. The overall goal is to design nanomaterials that are soluble in biological environments, non-toxic, stable, and fluorescent with no or minimal background fluorescence. While there exist many types of AuNP-fluorophore conjugates, the challenge with these is that the fluorescence behavior is altered upon surface conjugation. The fluorophore can interact with the AuNP surface to either undergo quenching or fluorescence enhancement depending on the physical property of the AuNP (size or shape) and the organic dye. There is still a critical need to determine how the size and shape affect the fluorescence behavior. More importantly, what features of dye and AuNP are needed to optimize the fluorescence behavior. Here we will present fluorescence spectroscopy studies evaluating the effect of AuNP size and shape on the fluorescence behavior of a variety of dyes. We will also present studies evaluating the impact of the donor-acceptor distance and concentration of dye on fluorescence quenching by AuNPs. We expect these studies will provide users with important design rules for designing AuNP-fluorophore conjugates for various applications where the features of the AuNP and fluorophores are equally important.<br/> <br/> <br/>

Optimizing gold nanoparticle-fluorophoreiInteractions to minimize fluorescence quenching

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.