Signal amplification allows for sensitive and reliable detection of low concentrations of analyte. Polymerization amplification is a relatively new approach that takes advantage of the growth of a long polymer chain from one initiation event. The Cooley Lab is developing and evaluating a detection assay using a new signal amplification strategy that enables simple, real-time monitoring of a fluorogenic polymerization. This method couples the polymerization initiation event to the detection of the desired analyte, making the formation of a visible, fluorescent polymer signal analyte presence. An uncontrolled photoinitiated polymerization mechanism was developed to decrease the time required for signal detection. The results of this uncontrolled polymerization strategy to improve the efficiency of the detection assay will be presented.

Uncontrolled photoinitiated fluorogenic polymerization for biomolecular detection

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.