This presentation describes work investigating the impact of quantum dots’ (QDs’) surface chemistry on their interactions with model membranes and bacterial cells. QDs are continuously being incorporated into biological assay, imaging, targeting, and treatment technologies. The varying methods in use to attain the aqueous miscible QDs of these technologies result in inherently different QD surface chemistries. These different surface chemistries impact the ability of the QDs to interact with biological models. While it is common practice to determine affinity and association constants for specific QDs in their intended technology, this study aims to concurrently investigate the impact varying QD surface chemistries have on the association and interaction of QDs with biologically-relevant models. Our studies use various optical and surface probing techniques to characterize the QDs’ surface chemistry and interaction with biological models, including dynamic light scattering, zeta potential, absorbance, emission, and FRET measurements. Our studies show how differences in charge, charge density, and surface ligand type may impact QD interactions with model membranes and human health-relevant bacterial and mammalian cells.

Quantifying nanoparticle surface chemistries' effect on association with biological models

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.