In this presentation, the ability of copper catalysts to mediate reductive carbonylation reactions of alkyl iodides will be discussed. First, a tandem carbonylation and reduction of alkyl iodides developed in the presence of a Cu catalyst to provide one carbon-extended alcohols will be presented. Mechanistic studies indicated that aldehydes served as intermediates and that radical atom transfer carbonylation (ATC) of alkyl iodides was involved. Second, a synergistic copper catalyzed carbonylation of alkyl iodides and reduction of nitroarenes to provide amides will be discussed. Both methods provided various carbonylated compounds in one pot under mild conditions. The supporting NHC ligands played an essential role in suppressing the side products in both C-C and C-N coupling reactions.

Copper catalyzed reductive carbonylation of alkyl iodides

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.