Because bacteria are increasingly becoming more resistant to traditional antibiotic regimens new types of antibiotic agents are needed1. Previous studies2,3 show that a small silver clusters of Ag29LA12 (LA = R-α-Lipoic Acid ) are effective against Methicillin-Resistant Staphylococcus aureus (MRSA). The silver clusters are stabilized with R-a-lipoic acid (1) ligands, widely known to have many beneficial biological properties in their own right. Herein is described our work to conjugate the R-a-lipoic acid with 6-aminopenicillanic acid (6-APA, 2) as outlined in Eq. 1. The expected synergies of a multipronged antibiotic agent (4) has also demonstrated4. Recovering the b-lactam conjugate (3) would then allow us to ligate the silver clusters as described in Eq. 2. Our efforts are centered on optimizing the reaction conditions for not only product yield but also resource efficiency.

Reactivation of obsolete penicillins with silver clusters

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.