Alpha emitting radionuclides with medically relevant half-lives are of renewed interest to the medical community for treating tumors and other diseases because they deposit large amounts of energy close to the location of the radioisotope. Some could be used for “theranostic” purposes, where both therapy and diagnostic imaging are supplied by the same isotope or different isotopes of the same element. While some of these isotopes are available via low energy protons or reactor routes, some of the most promising isotopes are inaccessible via these conventional routes. Production and supply of these unique isotopes is difficult due to the limited number of facilities with production capabilities, including targetry, accelerated heavy-ion beams of appropriate composition and energy, and radiochemistry expertise to isolate components of interest. The K150 at the Cyclotron Institute of Texas A&M is capable of generating reasonable intensities of various charged-ion beams of varied energies. Many isotopes of medical interest are within reach of the accelerator. A program is being developed to explore production of alpha emitters with medically relevant half-lives at Texas A&M. Preliminary studies on the feasibility of <sup>211</sup>At and <sup>149</sup>Tb production using beams from the K150 cyclotron have been performed. Preliminary results and future directions will be discussed, with an emphasis on current capabilities.

Developing isotope production capabilities with heavy-ion beams at Texas A&M University

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.