Polymers with designer architectures prepared by 'living' radical polymerization (LRP) have allowed the synthesis of complex architectures, and moreover the applications for such architectures are slowly being realized in biomedical applications. The seminar will present work on the synthesis of complex polymer architectures and their use in vaccine delivery and the delivery of siRNA. The seminar will all discuss new methods for production of multifunctional polymer nanostructures, and their application towards stem cell expansion and drug delivery. We have developed a new technique to produce nanoworms, nanorods, tadpoles, nanorattles and torroids at high weight fractions of polymer (&gt;10wt%) using the temperature-directed morphology transformation (TDMT) method. The nanostructures can be synthesized using multiple types of thermoresponsive MacroCTAs, allowing multiple andorthogonal chemical functionality on the nanostructure surface. Biomolecules and water-soluble molecules or polymers can be coupled to the nanostructures, and provide a strategy to produce designer structures for a<br/>wide range of bioapplications. The nanostructures can be dried, rehydrated and stored in water for 5 months without a change in shape. This method represents a new and an important synthetic development in the design of nanoobjects.

Polymer nanostructures for bioapplications: From stem cells enrichment to drug delivery

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.