Our group is interested in the development of macromolecular monomers that can be reacted into crosslinked polymer networks in the presence of living cells and tissues.  From a fundamental perspective, we seek to decipher the critical extracellular matrix (ECM) signals that are relevant for tissue development, regeneration, and disease and then design polymeric materials that integrate these signals.  From an applied perspective, we use this knowledge to design materials that can promote tissue regeneration and wound healing in vivo.  This talk will illustrate our recent efforts towards the synthesis of hydrogel networks for 4D cell culture and regenerative medicine, and how one can dynamically control biochemical and biophysical properties through orthogonal, photochemical click reaction mechanisms.  Some specific examples will include the design of hydrogels that promote musculoskeletal tissue regeneration, super-swelling matrices to visualize cell-matrix interactions with unprecedented resolution, and materials-directed growth of organoids from single stem cells.  These efforts will then be placed in the context of designing precision biomaterials to address demands for patient specific products and treatments. <br/>

Polymer networks as synthetic extracellular matrices: Biology in the 4<sup>th</sup> dimension

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Polymer networks as synthetic extracellular matrices: Biology in the 4th dimension

Polymer networks as synthetic extracellular matrices: Biology in the 4^th dimension