<br/>Lanthanide(III) ions are well known for their characteristic optical properties such as their thin and distinct emission bands and long lifetimes. These properties enable elementary discernable differences between lanthanide luminescence and the background fluorescence associated with biological systems. These attractive properties arise from the nature of lanthanide 4f valence electrons, but 4f–4f transitions are Laporte forbidden and have relatively weak intensities. Because of this low native absorbance, the use of chelating “antenna” ligands is common to excite these metal ions via energy transfer to create the desired luminescence. One promising group of antenna ligands are aromatic hydroximates that demonstrate a remarkable ability to excite lanthanide(III) ions in coordination complexes called metallacrowns, which have shown recent applicability in HeLa cell fixing and imaging. My project has two specific aims: (1) to make a new metallacrown that binds and sensitizes a lanthanide(III) ion towards further optical imaging applications of metallacrowns and (2) to make a sans-metallacrown aromatic hydroximate lanthanide coordination complex to examine the capabilities of this type of ligand as antenna on their own. To accomplish these aims, I will synthesize 8-quinaldic hydroxamic acid for use in the metallacrowns and 2-carboxybenzohydroxamic acid to assess to photophysics of hydroximates only as an antenna for different lanthanides. This presentation outlines my current results related to the synthetic route and characterization of these compounds.

Designing hydroximate antenna ligands for lanthanide-based luminescence

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

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