Post-translational modification is the addition or removal of small functional groups to proteins which regulates both protein function and cellular processes. Therefore, there is significant therapeutic interest in developing small molecules for the selective control of post-translational modifications. Towards this end, heterobifunctional molecules have been designed and synthesized in an attempt to bring about the selective post-translational modification of a protein of interest. Experiments were conducted for preliminary characterization of heterobifunctional molecules in cells. The current state of our synthetic and chemical biology studies will be presented.

Heterobifunctional molecules for selective post-translational modification

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.