The guaipyridine alkaloids are isolated from plants native to China and Southeast Asia. One member of this family, cananodine, has activity against two types of hepatocellular carcinoma cell lines. We are targeting the synthesis of the rupestines to see if they, too, have biological activity.  A total synthesis of rupestine D from 5-hexenenitrile and 5-hydroxy-2-methylpyridine is reported. An intramolecular Heck reaction forms the 7-membered carbocycle of the targets.  Progress on the synthesis of rupestines L and M from rupestine D is also reported.<br/>

Synthetic studies on guaipyridine alkaloids rupestines D, L and M

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.