Trends in drug discovery are changing rapidly. During the past decade, terms “Scaffold hopping,” “Escape the Flatland” and “Conformational restriction” have been introduced, and have already found huge practical application. In this context, in recent years medicinal chemists often use bicyclic Fsp3-rich building blocks in drug discovery projects. In this work, we have designed synthesized and applied novel multifunctional bicyclic cores for drug discovery. The key synthetic step in many scaffolds was a [2+2]-photochemical cycloaddition. Details of the synthesis and application of the obtained compounds will be discussed.

Photochemical synthesis of bicyclic amines for drug discovery

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.