Pronounced changes to a molecule’s chemical and biological properties are possible through the conversion of a carbon-hydrogen (C-H) bond into another functional group. Chemical transformation of the ubiquitous C-H bond is therefore an attractive field in organic synthesis due to nearly limitless applications. However, due to the diversity and number of C-H bonds present in most organic compounds, site selectivity has been an ongoing challenge within the field of C-H functionalization. Hydrogen atom transfer (HAT) methods which rely on a photocatalyst (PC) have recently provided a major advancement. We report a catalytic strategy for the aminoalkylation of adamantane and diamondoid derivatives. High efficiency and site selectivity are observed and deprotection of the reaction products provides aminoalkylated derivatives. Mechanistic studies and applications of this methodology for the synthesis of biologically-active structures will be discussed.

Aminoalkylation of adamantanes using visible-light photoredox and hydrogen atom transfer (HAT) dual catalysis

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.