A series of mononuclear and binuclear palladium and platinum complexes were synthesized and characterized and tested for potential anticancer activity. To test cancer cell inhibition, complexes were introduced to cell cultures of L1210 mouse lymphoma cells with varying metal complex concentrations (160µg/mL to 12.25µg/mL). L1210 cells were incubated for 24 hours, then counted after trypan blue staining to assess the percent survival of the cells. An SRB assay was used to determine HeLa cell survival 72 hours after incubation with the metal complexes and plates were read with a multiwell plate reader 96 hours after seeding. Complexes which exhibited increased activity in comparison to cisplatin were also reacted with 5’-GMP to assess DNA binding activity. The results of these studies will be discussed.

Synthesis, characterization and activity of new metallodrugs

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.