The copper catalyzed cycloaddition reaction of sulfonyl azides and terminal alkynes has been utilized in the synthesis of 1,2,3-triazoles and to access the highly reactive ketenimine intermediate. Ketenimines are very electrophilic and react with a wide range of nucleophiles that allow for their utility in total synthesis. Herein, we report a ketenimine/keteniminium strategy for the synthesis of indole and lactam naturally occuring compounds.

Synthesis of naturally occuring compounds via ketenimines

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.