Decay of an alpha emitting isotope has sufficient energy to break covalent bonding of the chelator resulting in release of a daughter for subsequent use. The kinetic energy of the recoiling daughter should allow the separation of the daughter isotope from an immobilized DOTA chelator on a substrate. We evaluated if a generator containing DOTA complexed Ac-225 was viable as a generator to supply Bi-213. 213Bi (t1/2=45.7 min) is used in alpha therapy and can be generated from 225Ac (t1/2=10 days). A DOTA-NCS chelator was immobilized on an amine functionalized SynPhase Lantern© via a thiourea linkage formed in 0.5 M carbonate buffer at pH 9.5. Then the 225Ac was loaded on the immobilized chelator at room temperature and at ~80°C from 0.1 M ammonium acetate at pH 6.5. The loading efficiency, retention of 225Ac and yield of 213Bi was determined by gamma spectroscopy. The results indicated the loading of 225Ac on the functionalized SynPhase Lantern©was significantly higher when the loading step was performed at elevated temperatures. The maximum yield of 213Bi was 50% and decreased with each elution. Breakthrough of the 225Ac parent was quantified and 95% of the 225Ac loaded (decay corrected) was retained on the generators over a month-long trial. We are currently evaluating if free DOTA on the SynPhase Lantern© influences the retention of 213Bi.

Development of a 213Bi generator based on recoil

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.