A variety of amine, alcohol, and related N- and O-nucleophiles can participate in room-temperature SNAr reactions with readily prepared and bench-stable 2-halo-N-(1-ethoxyvinyl)pyridinium salts. This procedure adds to the repertoire of synthetic methods for production of bioactive 2-aminopyridine and 2-alkoxypyridines, but offers notable advantages including a simple protocol, mild conditions, and avoidance of transition metals, coupling reagents, and their persistent impurities.

Direct nucleophilic aromatic substitution of 2-halo-N-(1-ethoxyvinyl)pyridinium salts with N- and O-nucleophiles

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.