Photodynamic therapy (PDT) is a non-invasive treatment for cancer and other diseases that relies on the sensitization of singlet oxygen. PDT is a highly localized type of treatment, and therefore has minimal side-effects so patients are able to recover relatively quickly. A limited number of phototherapeutic treatments are currently used to treat tumors close to the surface of the skin. However, these have their own shortcomings, and their practicality can suffer from difficult syntheses, high dark toxicity, low solubility in organic media and slow expulsion from the body. Most commercial PDT agents are not activated by the necessary wavelength (phototherapeutic window = 700 nm – 950 nm) required to penetrate deep-tissue tumors and development of improved photosensitizers is required. We have previously reported the structure of a palladium(II) tetrapyrrole complex comprised of a 10,10-dimethylbiladiene ligand (<b>Pd[DMBil1]</b>), that displays a very high singlet oxygen quantum yield of 80%. Upon bromination, this porphyrinoid is easily modified using metal-catalyzed cross-coupling chemistry. Such strategies allow the conjugated pi-system of the molecule to be extended, facilitating a shift in the absorbance spectrum of the complex into the phototherapeutic window. We have recently synthesized a suite of 10,10-dimethylbiladiene complexes with arylalkyne substituents that demonstrate promising absorption profiles and high singlet oxygen quantum yields. Among these, are a series of ether derivatives. The synthesis, photophysics and efforts to water solubilize these new derivates for biological studies as well as the photophysical characteristics of biladiene ether derivatives will be presented.<br/>

Novel organometallic tetrapyrrole complexes for phototherapeutic treatment of triple negative breast cancer

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.