A fundamental understanding of different factors that impact nanoparticle-based drug-delivery systems is of critical importance in designing new nanomedicine applications. In one study, surface-sensitive second harmonic generation (SHG) spectroscopy is used to investigate the molecular adsorption and transport of a small, drug-like cation, malachite green isothiocyanate (MGITC), in different liposome samples. The molecular transport of MGITC through the liposome bilayer is found to be more rapid in 1,2-dioleoyl-sn-glycero-3phospho-(1’rac-glycerol) and 1,2-dioleoyl-sn-glycero-3phospho-L-serine (DOPG and DOPS, respectively), whereas the molecular transport is slower in 1,2-dioleoyl-sn-glycero-3phosphocholine (DOPC). The modified Langmuir adsorption isotherm model is also used to determine the adsorption site densities and free energies of adsorption, where MGITC is found to have a lower free energy magnitude in DOPC than in DOPG and DOPS due to lower electrostatic interactions. Additionally, molecular dynamics (MD) simulations are also used to calculate the free energy profiles and molecular orientations of MGITC and malachite green (MG) in DOPG and DOPC liposomes phospholipids, which are in excellent agreement with the SHG measurements. In a second study, the retro-Diels-Alder thermal release of miRNA from the surface of gold and silver plasmonic nanoparticles is investigated at their corresponding plasmon resonances in real-time using surface-specific SHG spectroscopy. The experimental results indicate that the photothermal release of miRNA mimic at the corresponding plasmon resonances is more efficient for silver nanoparticles. Similar results are also obtained for additional characterization studies performed <i>in vitro</i> using fluorescence and confocal imaging techniques. In summary, these time-resolved studies highlight the importance of SHG as a sensitive and powerful tool to monitor the real-time study of colloidal nanoparticle-based drug-delivery systems.

Second harmonic generation studies of colloidal nanoparticle-based drug-delivery systems

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.