There are several possible routes to the synthesis of complex macromolecular assemblies.  These approaches can be parsed along a continuum arranged according to the information content of the building blocks.  One pot" self-assembly can be enabled if the building blocks have sufficient information content.  In the approach reported here, minimal spatial/localization information is encoded in the building blocks, requiring that such spatial information must be encoded through the sequence in which assembly reactions are performed.   Several parameters, including building block concentrations, building block programming, "build solution" composition and thermal annealing protocols were studied in order to optimize yield.   Fidelity of the intended constructs and yield were determined using atomic force microscopy, fluorescence microscopy and gel electrophoresis.

Toward sequential assembly of finite 1-D origami arrays of sensing nanostructures

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.