The ion transport process across the cell membrane is facilitated by a certain class of membrane-embedded proteins such as channels, carriers, etc.1 This process is essential for diverse biological functions such as maintenance of ion homeostasis of cells, sensory transduction, cell proliferation, osmotic stress response, etc. Homeostasis of sodium, potassium, calcium, and chloride are involved in apoptotic cell death.2 Evasion of apoptosis is long observed in cancers and chemotherapeutic agents that initiate apoptosis in cancer cells are already applied for the treatment of cancer.3 In this lecture, our recent approaches to the development of synthetic ion transporters would be discussed.4 Understanding of ion recognition and the mechanism of ion transport by these systems would be addressed. The effect of the transporter-mediated ion transport on cells would be discussed.5 Further, our strategies to activate the ion transport across the lipid membranes by certain types of stimuli would be presented.6,7,8 The effect of stimuli-responsive ion transport on cells would also be presented. The potential of such ion transport systems in targeting cancer would be addressed.

Synthetic ion transport systems for targeting cancer

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.