Virus filtration provides highly robust virus removal for many different virus types over wide ranges of operating conditions. One operating parameter that has been identified as potentially impacting viral clearance is transmembrane pressure. Using Planova 20N filters, we have previously shown that effective parvovirus removal can be expected under typical operating pressures of 0.5 to 1.0 bar but operating at lower pressures can impact parvovirus clearance under certain solution conditions. This phenomenon is hypothesized to occur due to low flow rates, which allow for diffusion of particles that would otherwise be trapped by hydrostatic forces. However, such a mechanism raises the question as to whether other mechanisms of flow rate reduction will also impact viral clearance. In this presentation, we discuss how other feedstock conditions, such as high product concentration and high aggregate content, can also reduce flow rate. Especially, we show that the mechanism by which flow reduction occurs can have different impacts on viral clearance capabilities.<br/>

Low flux impacts on virus filtration: Devil in the details

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.