Research and development of materials and strategies for designing real-time, amperometric sensors and biosensors for clinical and environmental applications continues to be a relevant scientific endeavor.  Within the specific aarea of biosensors, the field continues an emphasis on enzyme-based glucose detection as both a well-understood fundamental model system and as a clinically relevant sensing goal for diabetics.  It is rare, however, that the same strategies and materials utilized for such systems prove to be robust and versatile enough to be readily adapted to different target molecules with clinical relevance.  It follows then that a significant achievement would be the demonstration of a strategy and the use of materials that offer this type of versatility while maintaining sensing performance toward a molecule with bioanalytical or specific medical applications.  Our work explores layer-by-layer strategies for amperometric biosensor and sensor designs, where each layer or material within the composite film, including the incorporation of different nanomaterials, is functional with respect to sensing sensitivity and/or selectivity.  Additionally, this research also involves sensor development toward practical and effective clinical usage where the same constructs must be successfully adapted and miniaturized to needle or wire electrodes that can potentially function <i>in vitro </i>as a bedside device, within catheters for continuous, real-time measurements, or as an <i>in vivo </i>implant operating in biological media and physiologically relevant concentrations.     Fundamental studies proceed with a glucose model system before adapting the strategy and materials to specifically targeted clinical measurements including early detection/monitoring for sepsis, pregnancy-induced hypertension, and prostate cancer among others.

Incorporating functional nanomaterials in amperometric sensor designs: Adaptable templates for targeting clinically and environmentally relevant species

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.