Suzuki-Miyaura cross coupling is an essential,  widely applied C–-C bond forming reaction for modern synthetic chemistry that enables the facile, reliable, and straightforward synthesis of molecules used in many areas of science. Traditionally, these reactions use catalysts comprised of palladium. More recently, examples of catalysts based on palladium’s first row congener, nickel, are becoming increasingly commonplace. The cost, sustainability, and toxicity of palladium – and to a lesser extent, nickel – motivates the search for other metal catalysts capable of promoting Suzuki-Miyaura cross coupling. Our group reported the first example of a cobalt-catalyzed variant of this reaction in 2016, that uses neutral boron reagents as nucleophiles and a PNP-ligated cobalt complex as a catalyst. My presentation will focus on understanding and improving key fundamental transformations relevant to cross coupling, such as transmetalation and oxidative addition, as well as overall catalyst performance and scope.<br/>

Cobalt-catalyzed Suzuki-Miyaura cross coupling

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.