This investigation will involve the synthesis of several spermidine analogs produced using 100% ethanol as the solvent.  These nucleophilic substitution reactions with alkyl or acyl halides will produce bis(acetyl), bis(ethyl), and bis(benzyl) spermidine.  In this study, 100% ethanol was used as the reaction solvent this allowed for yields of the polyamine analogs to proceed in a greener solvent. There are many advantages for using alcohols over traditional volatile organic solvents in synthetic reactions. Alcohols are preferred solvents as they are more environmentally friendly, can be reclaimed or recycled, and reactions are run at lower temperatures.  It was also found, in this work that the use of 100% ethanol increased the product yield dramatically over other more toxic alcohol solvents used for previous studies in our laboratory.  This study also included polyamine analog exposure to a yeast cell model system to test for anti-Alzheimer activity. <br/> <br/>

Synthesis of three spermidine analogs as possible anti-Alzheimer agents

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.