Optically active synthesis of Spliceostatin derivatives via the construction of the tetrahydropyran (THP) core intermediate has been investigated. An optimization of a palladium-free transmetallative cross-coupling of the furan and diene allows for concise access to the THP core after minimal transformations. Formation of a sulfolene intermediate allows for protection over several steps to avoid the formation of an undesired triene byproduct. A detailed study of the Pd-free coupling will be presented.

Convenient synthesis of spliceostatin derivatives

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.