In biological systems, self-assembly processes exhibit features such as robust performance across a wide range of physical conditions, controlled stepwise assembly of hierarchical structures, and self-repair.  A key mechanism underlying these phenomena is the coupling of molecular self-assembly processes to signal transduction and gene expression networks.   DNA nanotubes, for which Watson-Crick hybridization of DNA complexes drives growth of a cylindrical lattice, are a model system for understanding how coupling self-assembly processes to designed chemical reaction networks can make it possible to achieve similar features <i>in vitro </i>by design.<br/>I will describe how coupling “buffering” monomer concentration using a self-regulating chemical reaction can allow nanotubes to grow at a fixed rate for a wide range of monomer concentrations from DNA nanotube seeds to act as templates for growth, thus controlling where nanotubes assemble.  I will also show of multivalent seeds and hierarchical assembly can be used to assemble hierarchical nanotube networks with control of assembly kinetics and network topology.  Finally, I will show how when nanotubes are damaged via enzymatic degradation, incorporation of fresh monomers can heal this damage, allowing nanotube structures to persist for long periods of time in environments where their components are chemically unstable.    <br/>

Coupling self-assembly of one-dimensional DNA fibers and fiber networks to regulating chemical reactions

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.