An unsolved grand challenge in chemistry is related to the control of chemical interactions in three-dimensional space as a function of time. In this presentation, we will report on an approach towards this goal, where a living organism is chemically transformed to display bioactive molecules on its surface. By using green algae and their remarkable ability of phototaxis, these modified organisms are able to respond to an outside stimulus such as light and can be moved around in three-dimensional space as a function of time. These ‘living drugs’ can be prepared by chemical synthesis via cell surface engineering, with the advantage of high spatial and temporal control, non-genetically modified organisms, and being non-hereditary and transient.

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Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.