A photo-catalyzed, linear selective hydrocarboxylation of electron-deficient alkenes employing CO<sub>2</sub> under flow conditions was developed. Several substrates participate in this process including unsaturated esters, unsaturated nitriles and enones and the reaction shows good functional group compatiblity. The derived carboxylic acids are readily converted to beta-lactones through an alpha-halogenation-beta-lactonization pathway. Importantly, the required electron-deficient alkene substrates for this process are readily accessible from alkene and ketone-containing natural products, which renders it possible to tag these natural products with beta-lactones for subsequent activity-based protein profiling (ABPP) studies.<br/>

Photo-catalyzed linear selective hydrocarboxylation of electron-deficient alkenes with CO2 under flow

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.