A new class of tricyclic aromatic thiazolium salts are conveniently obtained from air stable precursor via selective deprotection followed by oxidative disulfide coupling. Using this procedure, we are able to prepare a variety of thiazolium salts which contain both electron-withdrawing and electron donating aromatic substituents as well as aliphatic substituents. This method has proven to be tolerant towards many functional groups, thus allowing biologically relevant groups to be introduced either before or after the heterocycle formation.

Formation of tricyclic aromatic heterocycles mediated by oxidative disulfide coupling

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.