Melanoma is the deadliest form of skin cancer that effects the melanin producing cells in the human body and it accounts for 60 – 80% of all skin cancer related deaths. The prevalence of this disease has been increasing during the past several decades and the desired type of cell death in the elimination of these cells is apoptosis. Parabens are a class of organic, antimicrobial compounds widely used in industrial, food, and cosmetic products and have also displayed cytotoxic effects towards cancerous human cells. Cyclohexylmethylparaben is a newly synthesized paraben that has been shown to have inhibitory effects on the growth of human M624 melanoma cells. Human M624 melanoma cells were treated with 0.1, 0.25, 0.35, 0.45, 0.55, and 0.65 mM cyclohexylmethylparaben then cell proliferation was analyzed with clonogenic assays using a crystal violet dye. An IC50 value of 0.55 mM was calculated for cyclohexylmethylparaben in human M624 melanoma cells. Caspase-3 activity assays were performed to analyze the activation of the caspase pathway to determine if apoptosis occurred in human M624 melanoma cells.

Determination of the effect of cyclohexylmethylparaben on the caspase-3 cellular death pathway of M624 melanoma cells

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.