<br/>This viral respiratory disease, Influenza infection imposes a major threat both to the global health and economy causing a thousand deaths and millions of hospitalizations every year. The biggest challenge is that although there are vaccinations and drugs available for prevention, there is always a risk of a new strain of virus emerging at any time. The emergence of a drug-resistant influenza virus strain highlights the importance of developing an anti-influenza drug that can combat any influenza strain during a pandemic outbreak when vaccination is not immediately available. H1N1, H5N1, and H7N9 are influenza virus strains always at a high risk of undergoing mutation forming a resistance against the currently available antiviral drugs. The purpose of this research is to study the various binding sites or drug targets of these three strains and analyze the binding affinity of several available drugs such as Zanamivir, Oseltamivir as well as recently discovered protein M85 using molecular docking and drug repurposing. This would lead us to analyze improved bioisosteric replacements for these drug targets and a result help develop potential novel drugs.

Model docking and repurposing flu-drug for Influenza virus

Macromolecular Chemistry: The Second Century

[Author Benefits](https://scimeetings.acs.org/?utm_source=pubs_content_marketing&utm_medium=website&utm_campaign=0320_MCF_NPI_Launch_Spring_Homepage&ref=pubs_content_marketing)

[How to use SciMeetings](https://storage.googleapis.com/dl.morressier.com/acs/SciMeetings-ACSSpring2020-HowToGuide_M3020-Final.pdf)

[Frequently Asked Questions](https://storage.googleapis.com/dl.morressier.com/acs/SciMtng_ACSNMSp2020_FAQ_M3120_Final.pdf)

ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.