The purpose of this present work was to improve the stability of procyanidins loaded in gelatin-sodium alginate by complex coacervation technology followed by calcium ions crosslinking. Procyanidins microencapsules were evaluated by surface morphology, microencapsulation effect, intermolecular interaction, photothermal stability and inhibiting effects. Results showed that when the concentration of procyanidins and calcium ions were 6.25 mg/mL and 6 mM, the surface morphology was regular spherical network structure, and the relatively higher microencapsulation efficiency of procyanidins was 81.18±1.47% and 87.86±2.67%. The spectroscopy analysis demonstrated that there was a hydrophobic interaction existed in gelatin and procyanidins, electrostatic interaction between sodium alginate and gelatin, as well as the cross-linking of calcium ions, thus improving the stability of complex coacervations. The photothermal stability further proved that the stability of procyanidins was enhanced by embeding in complex aggregates. Meanwhile, the procyanidins microencapsules showed the ability in decreasing mitochondrial membrane potential induced by H<sub>2</sub>O<sub>2</sub> in PC-12 cells. This results in this study is helpful to understand calcium ions induced intermolecular interaction and improved the complex coacervations.

Procyanidins-loaded gelatin-sodium alginate complex coacervates induced by calcium ions: Structure and characterization

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.