Due to their essential roles in the treatment of gastrointestinal disorders, colitis, and other various conditions, bismuth compounds have played an important role in the field of medicine. Bismuth drugs such as: bismuth subsalicylate, colloidal bismuth subcitrate, and ranitidine bismuthcitrate, have been used to treat various gastrointestinal disorders. As such, many studies have been conducted to shed light in the interaction between bismuth and various amino acids found in the stomach. These techniques include inductively plasma mass spectrometry (ICP-MS), fluorescence, and immobilized metal affinity chromatography (IMAC). However, to our knowledge few studies have utilized electrochemistry as a method to study the interactions between bismuth and amino acids. As such, investigating the electrochemical behavior of bismuth compounds with amino acids and peptides may elucidate knowledge on the interactions of bismuth with various amino acids. Initial investigations have involved a study of the electrochemistry of bismuth compounds such as bismuth(III) nitrate and bismuth subsalicylate in aqueous solutions at various pH levels. The behavior at low pH (1 to 3) is important due to similar pH levels in the stomach. Initial results involving the electrochemical behavior of bismuth at pH 1 have been promising, and clear indications of the interaction of bismuth subsalicylate with L-cysteine have been obtained by voltammetric peak potential shifts. The effect of other amino acids such as histidine and tryptophan on bismuth electrochemical behavior is also under investigation.

Electrochemical investigations of Bi(III) interactions with amino acids

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.