(-)-Rishirilide A and (+)-rishirilide B are two complex polycyclic natural products, originally isolated from <i>Streptomyces</i> <i>Rishiriensis</i> OFR-1056. Rishirilide B has been the focus of a number of synthetic efforts by Danishefsky, Pettus, Nagasawa and others. However the total synthesis of rishirilide A has yet to be achieved. Herein we present our efforts towards the synthesis of the fused tricyclic core of rishirilide A based on a key Michael-Dieckmann cyclisation.

Michael-Dieckmann cyclisations in routes towards rishirilide A

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.