According to the World Health Organization, 1 in 10 medications in poor countries are falsified. Approximately 35,000 online pharmacies have appeared in the last decade. Thin-Layer Chromatography (TLC) is the main technique used to identify counterfeit pharmaceuticals, but it only separates the main components of a potential counterfeit, producing limited information as to the authenticity of a drug product. A novel sample preparation technique called Ice Concentration Linked with Extractive Stirrer (ICECLES) has been shown to work well for comprehensive analysis of substances. In this study, ICECLES was used to prepare aspirin samples from multiple manufacturers with analysis via gas chromatography-mass spectrometry (GC-MS). Multiple compounds were tentatively identified in the aspirin pills (N=8). Standards were used to attempt to identify these compounds definitively based on retention time and mass spectrometry, including comparison to the National Institute of Standards and Technology (NIST) online database. Currently, five of the eight chemical compounds have been identified conclusively.

Utilizing ice concentration linked with extractive stirrer (ICECLES) to identify the source of aspirin

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.