Kalkitoxin, a lipopeptide derived from the cyanobacterium family <i>Lyngbya majuscula</i>, displays antiproliferative properties in a biological setting. Its cytotoxic properties have been observed in ocean life and are also expanded to rat neurons and human colon cancer cell lines. The cancer-fighting implications have sparked efforts towards the synthesis of (+)-kalkitoxin, which can potentially be used to cease the production of ATP by the electron transport chain in cancer cells. These efforts to create an efficient, stereoselective process for the synthesis of the aliphatic core of kalkitoxin by use of asymmetric 1,4-conjugate addition reactions will be presented.

Efforts towards the synthesis of kalkitoxin

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.