Hydrogen sulfide (H2S), a gaseous signal-transmitter molecule (gasotransmitter), has pivotal roles in the human body by regulating physiological and pathological processes such as angiogenesis, inflammation and neurotransmission. With the discovery of the biological significance of H2S, the potential for H2S-based therapies has attracted growing attention. However, the lack of H2S delivery systems that enable controlled release of H2S at the site of interest limits its biomedical applications. One common approach is to use H2S donor compounds, such as anethole dithiolethione (ADT) derivatives, which generate H2S under physiological conditions. However, the uncontrolled rate of H2S release and toxic side effects of the donor compounds and/or their decomposition byproducts remain as the major problems associated with the use of small H2S donor compounds. To address this issue, we developed polymeric micelles carrying H2S-donating ADT groups (H2S donor micelles), which release H2S in a sustained manner under physiological conditions. Here, we report design, synthesis and characterization of polymeric H2S donor micelles. The proangiogenic activities of these micelles were also evaluated in the in vitro cell culture assays as well as the in ovo chick chorioallantoic membrane (CAM) assay.

Gasotransmitter hydrogen sulfide donor micelles with proangiogenic activity

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.