Current co-delivery systems, including polymer-based nanocarriers, lack the ability to precisely release their cargoes in a spatiotemporal manner. In this work, we modulate the release of multiple cargoes in both space and time by tailoring polymer design, nanoparticle composition, and stimulus application. The incorporation of an aromatic photo-cleavable group within the cationic block of the polymer enabled encapsulation of different therapeutics (<i>i.e., </i>nucleic acids and small molecule drugs), and photo-triggered changes in polymer structure resulted in release of the cargoes. Furthermore, a multi-layered nanocarrier was constructed with layers of varying photo-stabilities, imparting different release kinetics to therapeutics encapsulated within each layer. The ability of the photo-responsive nanocarriers to remain dormant until stimulus application enabled spatial control over the release of cargoes on cellular length scales, reducing concerns for off-target effects. Ultimately, this study can guide formulations for simultaneous co-delivery systems with controlled loading and customizable release of multiple therapeutics.

Controlled co-delivery of multiple therapeutics using photo-responsive polymers

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.