Many highly active pharmaceuticals are largely lipophilic, which poses a challenge in drug delivery. Some of these problems can be bypassed through the use of oligomeric phosphazene rings, specifically hexachlorophosphazene trimer ([PCl<sub>2</sub>N]<sub>3</sub>), as a drug delivery system. Phosphazenes possess many properties that make them potential candidates for drug delivery applications. Phosphazene rings themselves are inexpensive and easy synthetic targets, and the ease of substitution of phosphazene rings make them more versatile and modifiable. Tetraethyleneglycol monomethyl ether (TEGME) can be substituted onto the cyclophosphazene increasing the hydrophilicity of the ring system, while still leaving sites for further modifications. The remaining sites can be substituted with highly lipophilic drugs, including imidazoles. Imidazoles have recently gained attention and have been shown to be effective as anti-microbial and anti-cancer agents; however, they suffer from lowered solubility. The previously mentioned phosphazene system can be used to enhance the solubility of imidazoles, making them a viable drug candidate. Compounds from this study have been characterized via multi-nuclear NMR, IR, and mass spectrometry.

Synthesis of phosphazene drug delivery systems with the incorporation of imidazoles as potential anti-cancer agents

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.