The need for miniaturization of devices for future nanoelectronics applications has led to the search for new building blocks based on molecular electronic components. DNA represents a unique platform for creating such devices, because the base recognition, self-assembly, and structural control properties are unparalleled at the nanometer size scale. Experimentally, the native conductance of DNA-based devices is far below the conductance quantum, and as such charge transport in long, double-stranded (dsDNA) DNA is regarded as less-than-ideal for electronic purposes. DNA origami technique offers a unique opportunity for improving these systems as the nanoscale precision, self-assembled nanostructure decreases the reliance on conventional nanofabrication technologies that have lower resolution. DNA origami has been widely used for applications such as drug delivery, biosensing, and molds for nanoparticle synthesis. The high number of overlapping π-orbitals and the increased rigidity of the structure, may enhance the electrical property compared to normal, single-duplex DNA. Therefore, in this work, we seek to investigate the charge transport in DNA origami. Here, we examine the transport properties of a DNA origami structure that consists of four double-stranded DNA helices bundled together and bridged between two gold electrodes. The length of the DNA origami used is approximately 10 nm. We will discuss both the native conductance of these structures, and the effects of molecular intercalation on the transport properties. This work opens new possibilities for creating active electronic or sensing devices from DNA origami-based structures.<br/>

DNA origami as a building block for molecular electronics

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.