The abnormal level of some biochemical substances (i.e. biomarkers) in biofluids would potentially indicate the occurrence of diseases. And complex pathogenic analytes which make it difficult to achieve precise causes in time or perform any suitable treatments. Thus, it is appealing to develop chemical nose/tongue mimic sensor arrays capable of the pattern-recognition-based differentiation of multiple analytes. Herein, we have proposed a novel time-resolved fluorescence (TRF) orthogonal sensing array (Tb-GMP/dGMP) for pattern-recognition-based sensing of various metal ions in this work. The abundant functional groups on guanosine monophosphate (GMP) make it possible to interact with various metal ions. The subtle difference in the structure of GMP and deoxy-guanosine monophosphate (dGMP) coupled with Tb<sup>3+</sup> can be readily exploited to form two coordination polymers, which have been unveiled as two TRF sensing reporters (Tb-GMP and Tb-dGMP) in our study. In addition, upon integration of some thiol-affinity metal ions, Tb-GMP/dGMP can be further extended to construct two metal ion-involved pattern-recognition-based sensor arrays (Tb-GMP/dGMP-Cu, Tb-GMP/dGMP-Ag) for the TRF sensing different levels of disease-relevant biothiols in biofluids, illustrating the powerful and multifunctional capabilities of the Tb-GMP/dGMP system and would inspire simpler and more widespread designs of chemical nose/tongue-based applications.

Coordination polymers of Tb<sup>3+</sup>/Nucleotide as smart chemical nose/tongue toward pattern-recognition-based and time-resolved fluorescence sensing

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Coordination polymers of Tb3+/Nucleotide as smart chemical nose/tongue toward pattern-recognition-based and time-resolved fluorescence sensing

Coordination polymers of Tb³⁺/Nucleotide as smart chemical nose/tongue toward pattern-recognition-based and time-resolved fluorescence sensing