Pharmaceuticals are commonly sold in the form of crystalline and amorphous solids as hydrates, solvates, salts, polymorphs, or co-crystals. The major disadvantage of the solid form is the existence of polymorphism, which can often occur due to changes in the crystalline structure of the compound. In the case of pharmaceuticals, this can greatly affect and reduce the efficacy of the drug. This issue can be avoided by converting the solid-state pharmaceuticals into a liquid form (i.e., ionic liquid or IL). Along with the elimination of polymorphism, liquid state drugs have several additional advantages over their crystalline counterparts such as they can potentially have an increased bioavailability and can add new administration methods (i.e., cutaneous delivery) while the component ions retain their pharmacological function (therefore adding the potential for dual functionality).<br/>Aliphatic-based phenothiazine drugs exist in solid state as crystalline hydrochloride salts. Due to the presence of basic nitrogen sites within their structures, these drugs can be converted into liquid form when paired with appropriate organic anions (such as carboxylates) potentially forming either fully ionized compounds or liquid co-crystals. This research focuses on the liquid co-crystal forming potential of several phenothiazine drugs when paired with carboxylate anions of varying hydrophobic character. Several compounds were synthesized <i>via </i>metathesis reaction and known spectroscopic techniques were used to determine the degree of ionization in the synthesized compounds.<br/>

Spectroscopic characterization of phenothiazine co-crystals

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.