Biodegradable block copolymer nano-scaffolds provide excellent opportunity for anticancer drug delivery in biomedical applications. We have taken efforts to engineer polycaprolactone (PCL) based biodegradable block copolymer nano-assemblies as efficient intracellular enzyme-responsive nano-carriers to improve efficacies in cancer treatment. We have designed new carboxylic substituted caprolactone monomer through tailor-made approaches and employed them in ring opening polymerization to yield carboxylic functional di and tri-block copolymers. These di- and tri-block PCL copolymers were employed as scaffolds for synergistic combination therapy of antagonistic drugs like cisplatin and doxorubicin in the breast cancer treatment. These PCL block copolymers are capable of delivering both hydrophilic and hydrophobic drugs, and their drug release mechanism was understood in greater depth. Fluorescent pi-conjugated chromophores were introduced to study their cellular entry and also develop PCL based luminescent nano-probes for bioimaging. Star-shaped PCL block copolymers were built to address the role of single polymer nano-carriers to understand the role of polymer topology on the biodistribution, renal clearance, RES uptake and tumor accumulation. The presentation will be focused on the role of topology control on block copolymer macromolecular architectures to improve the drug delivery in cancer.

Functional polycaprolactone block copolymer nano-architectures in drug delivery

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.